Investigating Viral Genetic Diversity:
Our research is focused on understanding how viruses generate and maintain genetic diversity.
All virus populations display high genomic diversity, which provides opportunities for survival in the constantly changing environment. In many cases, such diversity results in the failure of antiviral treatment (resistance to vaccines and antiviral drugs) and the emergence of zoonotic viral pathogens.
DNA viruses and segmented RNA viruses exploit recombination and reassortment as mechanisms for diversity creation. We are interested in the mechanisms allowing DNA viral recombination and finding ways to inhibit these mechanisms.
Since the early weeks of the SARS-CoV2 pandemic, our lab attempted to identify novel in vitro models to assess differences among coronaviruses in replication and pathogenicity
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