Broadly speaking, we are interested in the structural biology of cellular signaling.
We have focused on several systems that play key roles in signal transduction. Our goals are to obtain a mechanistic understanding of these molecules; how they interact, transmit and respond to various cues on the most basic level of physics and chemistry; and how this understanding can forge greater progress in comprehending the general biology to which they are pivotal.
Currently we are researching four major areas:
- Calcium signalling, using voltage-dependent calcium channels and protein calcium sensors.
- Electrical signaling, using voltage-dependent potassium channels.
- Protein signaling, using G-protein regulation and protein kinases.
- Protein homeostasis, using the mitochondrial HSP60-HSP10 protein complexes.