My lab specializes in the study of endoplasmic reticulum (ER) protein folding, ER stress induction and the development of the unfolded protein response (UPR). ER stress develops and is a central player in the pathology of many diseases, such as neurodegenerative diseases.
We are studying the generation and possible intervention into UPR pathways in these diseases. ER stress also develops and is an integral part of the pathology of many viruses, including SARS-CoV-2. Together with Prof. Marcelo Ehrlich we are carrying on a project on modulation of UPR pathways to inhibit infection and replication of SARS-CoV-2.
We are testing the potential of experimental small molecule ER stress modulators to modify the cellular responses to infection and the consequent ability of coronaviruses to complete their life cycle.