Eran Bacharach is the head of a research laboratory for molecular virology at The Shmunis School of Biomedicine and Cancer Research, and teaches courses on microbiology, molecular virology and innate immunology, at the Faculty of Life Sciences, where he has been on the faculty since 2000.
He received his B.Sc., M.Sc. and Ph.D. degrees from the Hebrew University and conducted his postdoctoral research at the laboratory of Prof. Stephen P. Goff, Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University.
My lab investigates different aspects of virus replication, focusing on RNA viruses that infect humans and animals. Together with our collaborators, we employ molecular virology, imaging, and computational methodologies. Examples for research topics include:
- Development of a real-time imaging system for the detection of the retrovirus murine leukemia virus (MLV) virions and their pre-integration complexes. This system revealed a new role for the MLV p12 protein in the integration process of the virus into the mitotic chromosomes of the infected cells.
- Development of an improved reverse genetics system for the respiratory pathogen - the human metapneumovirus (hMPV) to study its assembly, replication, and innate immune responses to this pathogen.
- Discovery of a novel, emerging RNA virus that we named ‘tilapia lake virus (TiLV)’, which causes mass die-offs of Tilapia worldwide and threatens the global tilapia aquaculture. We developed diagnostic means for TiLV, are investigating basic biological questions concerning its replication, and are also engaged in developing vaccines against this pathogen.
- Investigation of the susceptibility of cancer cells to infection of (oncolytic) RNA viruses. We are engaged in developing a novel oncolytic RNA virus.
- We study host susceptibility to influenza A virus infections using a collection of a multi-parent panel of recombinant inbred mouse strains - the Collaborative Cross (CC). We are also engaged in a collaboration that develops small molecules that inhibit influenza A virus replication.