Prof. (Emeritus) Daniel Segal studied Biology at the Hebrew University where he obtained his PhD in Genetics. Following postdoc at Harvard University and three years at the Weizmann Institute, he joined Tel Aviv University at 1987.
Prof. Segal's studies defective folding of proteins, which causes various diseases. His lab focuses on proteins, which due to their misfolding, form toxic aggregates, in particular amyloid aggregates e.g. in Alzheimer and Parkinson diseases, Type 2 diabetes, cataract, cancer and HIV. We use the structural insights obtained in these studies for discovering small molecules that will inhibit the harmful aggregation. The efficacy of these molecules is examined in the test tube, in cell culture and in animals that serve as models for these maladies. The successful molecules serve as candidates for developing therapeutics for these diseases